作 者：Yongqiang Tian 1,2, Chunyun Zhang 1 and Mingquan Guo 1,*
论文题目：Comparative Analysis of Amaryllidaceae Alkaloids from Three Lycoris Species
刊物名称：Molecules
摘 要：The major active constituents from Amaryllidaceae family were reported to be Amaryllidaceae alkaloids (AAs), which exhibited a wide spectrum of biological activities, such as anti-tumor, anti-viral, and acetyl-cholinesterase-inhibitory activities. In order to better understand their potential as a source of bioactive AAs and the phytochemical variations among three different species of Lycoris herbs, the HPLC fingerprint profiles of Lycoris aurea (L. aurea), L. radiata, and L. guangxiensis were firstly determined and compared using LC-UV and LC-MS/MS. As a result, 39 peaks were resolved and identified as AAs, of which nine peaks were found in common for all these three species, while the other 30 peaks could be revealed as characteristic AAs for L. aurea, L. radiata and L. guangxiensis, respectively. Thus, these AAs can be used as chemical markers for the identification and quality control of these plant species. To further reveal correlations between chemical components and their pharmaceutical activities ofthese species at the molecular level, the bioactivities of the total AAs from the three plant species were also tested against HepG2 cells with the inhibitory rate at 78.02%, 84.91% and 66.81% for L. aurea, L. radiata and L. guangxiensis, respectively. This study firstly revealed that the three species under investigation were different not only in the types of AAs, but also in their contents, and both contributed to their pharmacological distinctions. To the best of our knowledge, the current research provides the most detailed phytochemical profiles of AAs in these species, and offers valuable information for future valuation and exploitation of these medicinal plants.
参与单位：
1 Sino-Africa Joint Research Center/Key Laboratory of Plant Germplasm Enhancement and Specialty
Agriculture, Wuhan Botanical Garden, Chinese Academy of Sciences, Wuhan 430074, China;
xiaoqiangtian2013@163.com (Y.T.); cyzhang@wbgcas.cn (C.Z.)
2 Graduate University of Chinese Academy of Sciences, Beijing 100049, China
